The Role of CRISPR-Cas Systems in Virulence of Pathogenic Bacteria

@article{Louwen2014TheRO,
  title={The Role of CRISPR-Cas Systems in Virulence of Pathogenic Bacteria},
  author={Rogier Louwen and Raymond H. J. Staals and Hubert Ph. Endtz and Peter van Baarlen and John van der Oost},
  journal={Microbiology and Molecular Biology Reviews},
  year={2014},
  volume={78},
  pages={74 - 88}
}
SUMMARY Clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated (Cas) genes are present in many bacterial and archaeal genomes. Since the discovery of the typical CRISPR loci in the 1980s, well before their physiological role was revealed, their variable sequences have been used as a complementary typing tool in diagnostic, epidemiologic, and evolutionary analyses of prokaryotic strains. The discovery that CRISPR spacers are often identical to sequence fragments… 

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