The Role of Bystander Effects in the Antitumor Activity of the Hypoxia-Activated Prodrug PR-104

Activation of prodrugs in tumors (e.g., by bioreduction in hypoxic zones) has the potential to generate active metabolites that can diffuse within the tumor microenvironment. Such "bystander effects" may offset spatial heterogeneity in prodrug activation but the relative importance of this effect is not understood. Here, we quantify the contribution of… CONTINUE READING