The Role of Bacteria and Pattern Recognition Receptors in GvHD

@inproceedings{Holler2010TheRO,
  title={The Role of Bacteria and Pattern Recognition Receptors in GvHD},
  author={E. Holler and Karin Landfried and J K Meier and Martin Hausmann and Gerhard Rogler},
  booktitle={International journal of inflammation},
  year={2010}
}
Graft-versus-Host Disease (GvHD) is the most serious complication of allogeneic stem cell transplantation (SCT) and results from an activation of donor lymphocytes by recipient antigen-presenting cells (APCs). For a long time, it has been postulated that the intestinal microflora and endotoxin exert a crucial step in this APC activation, as there is early and severe gastrointestinal damage induced by pretransplant conditioning. With the detailed description of pathogen-associated molecular… CONTINUE READING

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