The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy

  title={The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy},
  author={Kosuke Yamahara and Mako Yasuda and Shinji Kume and Daisuke Koya and Hiroshi Maegawa and Takashi Uzu},
  booktitle={Journal of diabetes research},
Diabetic nephropathy is a leading cause of end-stage renal disease worldwide. The multipronged drug approach targeting blood pressure and serum levels of glucose, insulin, and lipids fails to fully prevent the onset and progression of diabetic nephropathy. Therefore, a new therapeutic target to combat diabetic nephropathy is required. Autophagy is a catabolic process that degrades damaged proteins and organelles in mammalian cells and plays a critical role in maintaining cellular homeostasis… CONTINUE READING