The Role of Autophagy in Aging

@article{Bergamini2007TheRO,
  title={The Role of Autophagy in Aging},
  author={Ettore Bergamini and Gabriella Cavallini and Alessio Donati and Zina Gori},
  journal={Annals of the New York Academy of Sciences},
  year={2007},
  volume={1114}
}
Abstract:  Aging denotes a postmaturational deterioration of cells and organisms with the passage of time, an increased vulnerability to challenges and prevalence of age‐associated diseases, and a decreased ability to survive. Causes of this deterioration may be found in an enhanced production of reactive oxygen species (ROS) and oxidative damage and incomplete “housekeeping.” Caloric restriction is the most robust anti‐aging intervention known so far. Similar beneficial effects on median and… Expand
Autophagy and aging: Maintaining the proteome through exercise and caloric restriction
TLDR
The longevity effects of exercise and CR may stem from the maintenance of the proteome by balancing the synthesis and recycling of intracellular proteins and thus may represent practical means to promote longevity. Expand
Towards an understanding of the anti-aging mechanism of caloric restriction.
TLDR
It is suggested that the pharmacological intensification of suppression of aging by the stimulation of autophagy might prove to be a big step towards retardation of aging and prevention of age-associated diseases in humans. Expand
How to live long and prosper: autophagy, mitochondria, and aging.
TLDR
The role of autophagy is reviewed, with an emphasis on the signaling pathways that are involved in regulation, and the consequences ofautophagy induction with regard to aging. Expand
An insight into the role of autophagy in cell responses in the aging and neurodegenerative brain.
TLDR
The critical changes of autophagy in the aging and neuro-degenerative brain and the role of key regulators of autphagy, which are directly related to oxidative stress, inflammation and longevity pathways are reviewed. Expand
Life, death and burial: multifaceted impact of autophagy.
TLDR
It is still unclear whether autophagic vacuolization has a causative role in cell death or whether it represents the ultimate attempt of cells to cope with lethal stress, but it might well represent a pro-survival mechanism, by providing metabolic supplies during whole-body nutrient deprivation. Expand
Effect of aging and anti-aging caloric restriction on the endocrine regulation of rat liver autophagy.
TLDR
Results show that in ad libitum-fed rats sensitivity of autophagy to glucagon and insulin declines by one order of magnitude in older rats, and it is concluded that changes in the sensitivity in the aging process. Expand
Methods to Assess Autophagy and Chronological Aging in Yeast.
TLDR
Established protocols used to evaluate a link between lifespan extension and autophagy in yeast are recapped and methods to quantify autophagic flux are described. Expand
Mitochondrial responsibility in ageing process: innocent, suspect or guilty
TLDR
The importance of mitochondria to explain the ageing process in different models or organisms is shown and it is discussed if the cause of aging is dependent on mitochondrial dysfunction of if the mitochondrial changes observed with age are a consequence of events taking place outside the mitochondrial compartment. Expand
Regulation of the aging process by autophagy.
TLDR
The interactions of the signaling network involving longevity factors SIRT1, mTOR, FoxO3, NF-kappaB and p53 in the regulation of autophagy are examined in detail to discuss the possibility that these well-known stress resistance and longevity factors regulate the aging process via Autophagy. Expand
Role of Sirt1 During the Ageing Process: Relevance to Protection of Synapses in the Brain
TLDR
Nutritional modulation through calorie restriction has been shown to be effective as an anti-ageing factor, promoting longevity and protecting against neurodegenerative pathology in yeast, nematodes and murine models. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 54 REFERENCES
The involvement of macroautophagy in aging and anti-aging interventions.
  • A. Donati
  • Biology, Medicine
  • Molecular aspects of medicine
  • 2006
TLDR
According to this hypothesis, it is shown that life-long weekly administration of an anti-lipolytic drug decreases glucose and insulin levels, stimulates autophagy and intensifies anti-aging effects of submaximal CR. Expand
Ageing-related changes in the in vivo function of rat liver macroautophagy and proteolysis
TLDR
Data may support the hypothesis that ad libitum feeding accelerates the rate of ageing by raising insulin plasma levels and suppressing autophagy and membrane maintenance, and that calorie restriction may break this vicious circle. Expand
Age-related changes in the autophagic proteolysis of rat isolated liver cells: effects of antiaging dietary restrictions.
TLDR
DR significantly improves the susceptibility of liver cells to lysosomal degradation, and it prevents decline with increasing age, so it is suggested that improved liver autophagy and lysOSomal degradation might be part of the antiaging mechanisms of DR. Expand
Targets for antiageing drugs
  • E. Bergamini
  • Biology, Medicine
  • Expert opinion on therapeutic targets
  • 2005
The process of ageing denotes a postmaturational deterioration of cells and organisms with the passage of time, an increased vulnerability to challenges and a decreased ability to survive. Causes mayExpand
Age-related changes in the regulation of autophagic proteolysis in rat isolated hepatocytes.
TLDR
The conclusion is that altered regulation of autophagic proteolysis decreases susceptibility of older cells to lysosomal degradation, and it may lead to the accumulation of altered organelles and membranes. Expand
The protection of rat liver autophagic proteolysis from the age-related decline co-varies with the duration of anti-ageing food restriction
TLDR
Results show that the maximum attainable rate and the regulation of AP decline with increasing age; that changes are prevented by anti-ageing CR initiated at young age, and that the protective effects of CR change with the duration of diet. Expand
Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging.
TLDR
The term "mitophagy" is proposed to emphasize the non-random nature of the selective autophagy of mitochondria and may play a key role in retarding accumulation of somatic mutations of mtDNA with aging. Expand
The pleiotropic role of autophagy: from protein metabolism to bactericide
  • N. Mizushima
  • Biology, Medicine
  • Cell Death and Differentiation
  • 2005
TLDR
The biological significance of autophagy from yeast to higher eukaryotes is discussed and several other roles for autophile have been discovered, such as presentation of endogenous antigens and degradation of invasive bacteria. Expand
Stimulation of macroautophagy can rescue older cells from 8-OHdG mtDNA accumulation: a safe and easy way to meet goals in the SENS agenda.
TLDR
It is concluded that the age-related changes in mtDNA and function are likely to be the consequence of a failure of macroautophagy in the recognition and disposal of a small number of severely injured mitochondria, and that easy and safe ways are available to counteract this change. Expand
The Molecular Mechanism of Autophagy
TLDR
This review focuses on the yeast system, which has provided most of the insight into the molecular mechanism of autophagy and the Cvt pathway, and highlights the most recent additions to the current knowledge of both pathways. Expand
...
1
2
3
4
5
...