The Role of Aryl Hydrocarbon Receptor in the Pathogenesis of Cardiovascular Diseases

@article{Korashy2006TheRO,
  title={The Role of Aryl Hydrocarbon Receptor in the Pathogenesis of Cardiovascular Diseases},
  author={Hesham M. Korashy and Ayman O. S. El-Kadi},
  journal={Drug Metabolism Reviews},
  year={2006},
  volume={38},
  pages={411 - 450}
}
Numerous experimental and epidemiological studies have demonstrated that polycyclic aromatic hydrocarbons (PAHs), which are major constituents of cigarette tobacco tar, are strongly involved in the pathogenesis of the cardiovascular diseases (CVDs). Knowing that PAH-induced toxicities are mediated by the activation of a cytosolic receptor, aryl hydrocarbon receptor (AhR), which regulates the expression of a group of xenobiotic metabolizing enzymes (XMEs) such as CYP1A1, CYP1A2, CYP1B1, NQO1… Expand
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Evidence of selective activation of aryl hydrocarbon receptor nongenomic calcium signaling by pyrene
TLDR
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2,3,7,8-Tetrachlorodibenzo-p-dioxin and beta-naphthoflavone induce cellular hypertrophy in H9c2 cells by an aryl hydrocarbon receptor-dependant mechanism.
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  • Toxicology in vitro : an international journal published in association with BIBRA
  • 2010
TLDR
Investigation of whether AhR activation causes a hypertrophic effect in H9c2 cells and related this effect to changes in CYP gene expression found that resveratrol, an AhR antagonist, protected the cells from TCDD-induced hypertrophy. Expand
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