The Role of Aryl Hydrocarbon Receptor in the Pathogenesis of Cardiovascular Diseases

  title={The Role of Aryl Hydrocarbon Receptor in the Pathogenesis of Cardiovascular Diseases},
  author={H. Korashy and A. El-Kadi},
  journal={Drug Metabolism Reviews},
  pages={411 - 450}
  • H. Korashy, A. El-Kadi
  • Published 2006
  • Biology, Medicine
  • Drug Metabolism Reviews
  • Numerous experimental and epidemiological studies have demonstrated that polycyclic aromatic hydrocarbons (PAHs), which are major constituents of cigarette tobacco tar, are strongly involved in the pathogenesis of the cardiovascular diseases (CVDs). Knowing that PAH-induced toxicities are mediated by the activation of a cytosolic receptor, aryl hydrocarbon receptor (AhR), which regulates the expression of a group of xenobiotic metabolizing enzymes (XMEs) such as CYP1A1, CYP1A2, CYP1B1, NQO1… CONTINUE READING
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