The Role of Anticonvulsant Drugs in Anxiety Disorders: A Critical Review of the Evidence

@article{Mula2007TheRO,
  title={The Role of Anticonvulsant Drugs in Anxiety Disorders: A Critical Review of the Evidence},
  author={Marco Mula and Stefano Pini and Giovanni Battista Cassano},
  journal={Journal of Clinical Psychopharmacology},
  year={2007},
  volume={27},
  pages={263-272}
}
Antiepileptic drugs (AEDs) have been successfully used in the treatment of mood disturbances, leading clinicians and researchers to investigate their use in other psychiatric disorders. This article reviews the literature about the potential efficacy of AEDs in anxiety disorders. An updated MEDLINE search (January 1970 to September 2006) using the terms "panic disorder," "agoraphobia," "posttraumatic stress disorder," "obsessive-compulsive disorder," "generalized anxiety disorder," "social… 
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References

SHOWING 1-10 OF 99 REFERENCES

Positive and negative psychiatric effects of antiepileptic drugs in patients with seizure disorders.

The testable hypothesis that better psychiatric outcomes in seizure disorder patients could be achieved is suggested by treating patients with baseline "activated" profiles with "sedating" predominantly GABAergic drugs, and conversely those with baseline 'sedated' or anergic profiles with 'activating' predominantly antiglutamatergic agents.

Carbamazepine in obsessive-compulsive disorder

Psychiatric adverse events during vigabatrin therapy.

Vigabatrin use in treatment-refractory partial epilepsy is associated with increased occurrence of depression and of psychosis, although the frequency of psychosis is apparently lower than previously reported.

Psychiatric Syndromes Related to Antiepileptic Drugs

All antiepileptic drugs may provoke positive or negative psychiatric reactions in individual patients. These psy‐chotropic effects are not simply idiosyncratic but depend on the drug's anticonvulsive…

Anticonvulsants in anxiety disorders

Past and current research being done in the novel area of psychopharmacology is reviewed, indicating a potential role for anticonvulsants in the treatment of anxiety as monotherapy or augmentation therapy; however, these early findings must be supported by additional investigation in large-scale, placebo-controlled studies.

A preliminary study of lamotrigine for the treatment of posttraumatic stress disorder

Gabapentin in the Treatment of Posttraumatic Stress Disorder.

  • T. Berigan
  • Psychology, Medicine
    Primary care companion to the Journal of clinical psychiatry
  • 2000
A patient diagnosed with posttraumatic stress disorder (PTSD) who had been taking multiple medications with little clinical response was placed on gabapentin treatment with beneficial results, and noted a distinct reduction in nightmares and flashbacks, and his depression improved.

An open-label study of levetiracetam for the treatment of social anxiety disorder.

This pilot study supports the safety and potential efficacy of a novel agent, levetiracetam, for the treatment of social anxiety disorder and warrants systematic evaluation as a treatment option for anxiety disorders.

Tiagabine for posttraumatic stress disorder: effects of open-label and double-blind discontinuation treatment

Findings suggest a possible role for the SGRI tiagabine in the treatment of PTSD as the role of GABAergic drugs in PTSD is poorly defined and larger, randomized, double-blind, placebo-controlled trials are needed.

Treatment of posttraumatic stress disorder with phenytoin: an open-label pilot study.

Findings suggest that phenytoin may be efficacious in the treatment of PTSD, possibly mediated through its antiglutamatergic effects.
...