The Role of Annexin A2 in Tumorigenesis and Cancer Progression

  title={The Role of Annexin A2 in Tumorigenesis and Cancer Progression},
  author={Noor A. Lokman and Miranda Ween and Martin K. Oehler and Carmela Ricciardelli},
  journal={Cancer Microenvironment},
Annexin A2 is a calcium-dependent, phospholipid-binding protein found on various cell types. It is up-regulated in various tumor types and plays multiple roles in regulating cellular functions, including angiogenesis, proliferation, apoptosis, cell migration, invasion and adhesion. Annexin A2 binds with plasminogen and tissue plasminogen activator on the cell surface, which leads to the conversion of plasminogen to plasmin. Plasmin is a serine protease which plays a key role in the activation… CONTINUE READING


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Characterization of a new candidate target for pancreatic cancer immunotherapy: Tyrosine phosphorylation regulates cell surface translocation

  • L Zheng, L Huang, G Mo
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