The Role of Angiopoietins as Potential Therapeutic Targets in Renal Cell Carcinoma1

@inproceedings{Wang2014TheRO,
  title={The Role of Angiopoietins as Potential Therapeutic Targets in Renal Cell Carcinoma1},
  author={Xiaoen Wang and Andrea J. Bullock and Liang Zhang and Lin Heng Wei and Dongyin Yu and Kedar Mahagaokar and David C. Alsop and James Walter Mier and Michael B. Atkins and Angela Coxon and Jon Oliner and Rupal S. Bhatt},
  booktitle={Translational oncology},
  year={2014}
}
Angiopoietin 2 (Ang2) is a secreted glycoprotein upregulated at sites of angiogenesis and has been implicated in cancer neovascularization. Recent studies have suggested efficacy of combined Ang and vascular endothelial growth factor receptor (VEGFR) inhibition for patients with metastatic renal cell carcinoma (mRCC). We measured Ang2 expression in human tissue and plasma, and tested the effect of dual Ang1/2 (trebananib; AMG386) or Ang2 alone (L1-7) inhibition with VEGFR inhibition on murine… CONTINUE READING