The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy.

@article{Sengupta2016TheRO,
  title={The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy.},
  author={U. Sengupta and Ashley N. Nilson and Rakez Kayed},
  journal={EBioMedicine},
  year={2016},
  volume={6},
  pages={42-49}
}
The incidence of Alzheimer's disease (AD) is growing every day and finding an effective treatment is becoming more vital. Amyloid-β (Aβ) has been the focus of research for several decades. The recent shift in the Aβ cascade hypothesis from all Aβ to small soluble oligomeric intermediates is directing the search for therapeutics towards the toxic mediators of the disease. Targeting the most toxic oligomers may prove to be an effective treatment by preventing their spread. Specific targeting of… CONTINUE READING