The Role of Altered Cell–Cell Communication in Melanoma Progression

  title={The Role of Altered Cell–Cell Communication in Melanoma Progression},
  author={Nikolas K. Haass and Keiran S. M. Smalley and Meenhard Herlyn},
  journal={Journal of Molecular Histology},
Under normal homeostasis, melanocyte growth and behaviour is tightly controlled by the surrounding keratinocytes. Keratinocytes regulate melanocyte behaviour through a complex system of paracrine growth factors and cell–cell adhesion molecules. Pathological changes, leading to development of malignant melanoma, upset this delicate homeostatic balance and can lead to altered expression of cell–cell adhesion and cell–cell communication molecules. In particular, there is a switch from the E… CONTINUE READING

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