The Role of AIRE in the Immunity Against Candida Albicans in a Model of Human Macrophages

Abstract

Autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a primary immunodeficiency caused by mutations in the autoimmune regulator gene (AIRE). Patients with AIRE mutations are susceptible to Candida albicans infection and present with autoimmune disorders. We previously demonstrated that cytoplasmic AIRE regulates the Syk-dependent… (More)
DOI: 10.3389/fimmu.2018.00567

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