The Role of α1-Adrenoceptor Antagonists in the Treatment of Prostate and Other Cancers

@inproceedings{Batty2016TheRO,
  title={The Role of α1-Adrenoceptor Antagonists in the Treatment of Prostate and Other Cancers},
  author={Mallory Batty and Rachel Pugh and Ilampirai Rathinam and Joshua Simmonds and Edwin Walker and Amanda Forbes and Shailendra Anoopkumar-Dukie and Catherine M. McDermott and Briohny H. Spencer and David A. Christie and Russ Chess-Williams},
  booktitle={International journal of molecular sciences},
  year={2016}
}
This review evaluates the role of α-adrenoceptor antagonists as a potential treatment of prostate cancer (PCa). Cochrane, Google Scholar and Pubmed were accessed to retrieve sixty-two articles for analysis. In vitro studies demonstrate that doxazosin, prazosin and terazosin (quinazoline α-antagonists) induce apoptosis, decrease cell growth, and proliferation in PC-3, LNCaP and DU-145 cell lines. Similarly, the piperazine based naftopidil induced cell cycle arrest and death in LNCaP-E9 cell… CONTINUE READING
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  • Cell Signalling Technology. Regulation of Apoptosis
  • 11. 2012. Available online: http://www.cellsignal…
  • 2016
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