• Corpus ID: 46675759

The Risk of Hepatotoxicity with Fluoroquinolones : A National Case-Control Safety Study

  title={The Risk of Hepatotoxicity with Fluoroquinolones : A National Case-Control Safety Study},
  author={Haley J. Morrill and Aisling R. Caffrey and Brian J. Quilliam and Kerry L. LaPlante},
Purpose. Fluoroquinolones are generally considered safe and well-tolerated. However, suspected fluoroquinolone induced hepatotoxicity has been increasingly reported, but data are lacking. Thus, the objective of this study was to assess the risk of hepatotoxicity in patients using fluoroquinolones compared to non-users. Methods. National Veterans Affairs (VA) hospital admissions were assessed between January 1, 2002 and December 31, 2008. Our case-control study matched patients with a primary… 

Perspectives of Healthcare Professionals Regarding Factors Associated with Antimicrobial Resistance (AMR) and Their Consequences: A Cross Sectional Study in Eastern Province of Saudi Arabia

Factors reported in the literature associated with inappropriate prescribing of antimicrobials include physicians with less experience, uncertain diagnosis, and patient caregiver influences on physicians’ decisions, which contribute to AMR from participants’ perspectives.

The Healthcare Professionals’ Perspectives on Antimicrobial Resistance (AMR) Associated Factors and Their Consequences: A Cross Sectional Study in Eastern Province of Saudi Arabia

The current study has identified comprehensive education and training needs for healthcare providers about antimicrobial resistance and poor skills and knowledge were a key factor that contributed to the inappropriate use and overuse of antimicrobials.

In vivo study of hybrid biomaterial scaffold bioactive glass–chitosan after incorporation of Ciprofloxacin

The incorporation of the Ciprofloxacin in the BG–CH induces a retarding effect on the formation of the hydroxyapatite, and consequently on the ossification, without any side effects on the liver–kidney.



Fluoroquinolone therapy and idiosyncratic acute liver injury: a population-based study

Among older outpatients with no evidence of liver disease, moxifloxacin and levofloxACin were associated with an increased risk of acute liver injury relative to clarithromycin, and there was no such risk associated with the use of either ciprofloxacins or cefuroxime axetil.

Clinical and histopathologic features of fluoroquinolone-induced liver injury.

  • Eric S. OrmanH. Conjeevaram P. Hayashi
  • Medicine, Biology
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2011

Cohort study of hepatotoxicity associated with nimesulide and other non-steroidal anti-inflammatory drugs

The risk of liver injury in patients taking nimesulide and other non-steroidal anti-inflammatory drugs is small and the rate ratio for all hepatopathies and more severe liver injury was 1.3 to 1.4.

Safety Profile of the Respiratory Fluoroquinolone Moxifloxacin

The data show that using moxifloxacin, in its accepted indications and following the corresponding guidelines, should not be associated with an excessive incidence of drug-related adverse reactions, provided the clinician takes care in identifying patients with known risk factors and pays due attention to the contraindications and warnings mentioned in the labelling.

Antimicrobial safety: focus on fluoroquinolones.

  • R. OwensP. Ambrose
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2005
The currently marketed quinolones are well tolerated, with safety profiles similar to those of other antimicrobial classes, although adverse effects are unusual, some, including tendinitis and CNS-related effects, are more common with quInolones than with other antimacterial classes.

Temafloxacin syndrome: review of 95 cases.

The data suggest that temafloxacin causes immune hemolytic anemia, most likely secondary to immune complex formation, and is withdrawn from the market worldwide.

Association between tetracycline or doxycycline and hepatotoxicity: a population based case–control study 1

The objective of this study is to determine the difference in risk of hepatotoxicity in patients receiving doxycycline or tetracycline using California Medicaid claims.

Hepatic safety of antibiotics used in primary care

Patients at risk are mainly those with previous experience of hepatotoxic reaction to antibiotics, the aged or those with impaired hepatic function in the absence of close monitoring, making it important to carefully balance potential risks with expected benefits in primary care.

The safety profile of moxifloxacin and other fluoroquinolones in special patient populations

  • P. Iannini
  • Medicine, Biology
    Current medical research and opinion
  • 2007
Fluoroquinolones, are associated with rare, but clinically important, adverse events in special patient populations (including the elderly; those with hepatic, renal, or glycemic disorders; and those at risk for cardiovascular events); recognition of differences in the clinical efficacy and safety profiles of fluoroquolones inSpecial patient populations should lead to better antimicrobial agent selection.

Hepatotoxicity Associated with Metformin Therapy in Treatment of Type 2 Diabetes Mellitus with Nonalcoholic Fatty Liver Disease

A 61-year-old obese man presented with jaundice, nausea, fatigue, and an unintentional weight loss 2 weeks following initiation of metformin, and laboratory findings revealed aminotransferase values 10–15 times the upper limit of normal.