The Risk of Fractures Associated with Thiazolidinediones: A Self-controlled Case-Series Study

@inproceedings{Douglas2009TheRO,
  title={The Risk of Fractures Associated with Thiazolidinediones: A Self-controlled Case-Series Study},
  author={Ian J. Douglas and Stephen Jw Evans and Stuart J. Pocock and Liam Smeeth},
  booktitle={PLoS medicine},
  year={2009}
}
BACKGROUND The results of clinical trials have suggested that the thiazolidinedione antidiabetic agents rosiglitazone and pioglitazone are associated with an increased risk of fractures, but such studies had limited power. The increased risk in these trials appeared to be limited to women and mainly involved fractures of the arm, wrist, hand, or foot: risk patterns that could not be readily explained. Our objective was to further investigate the risk of fracture associated with… CONTINUE READING
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