The Rise and Fall of Oral Ketoconazole

@article{Gupta2015TheRA,
  title={The Rise and Fall of Oral Ketoconazole},
  author={A. Gupta and Danika C A Lyons},
  journal={Journal of Cutaneous Medicine and Surgery},
  year={2015},
  volume={19},
  pages={352 - 357}
}
  • A. Gupta, Danika C A Lyons
  • Published 2015
  • Medicine
  • Journal of Cutaneous Medicine and Surgery
  • Background: Ketoconazole was the first broad-spectrum oral antifungal agent available to treat systemic and superficial mycoses. Evidence of hepatotoxicity associated with its use emerged within the first few years of its approval. Growing evidence of serious side effects including endocrine dysregulation, several drug interactions, and death led to the review of oral ketoconazole in 2011. Objective: This article chronicles the use of oral ketoconazole from its introduction to its near… CONTINUE READING
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    References

    SHOWING 1-10 OF 51 REFERENCES
    Drug safety assessment of oral formulations of ketoconazole
    • 31
    History of the development of azole derivatives.
    • J. Maertens
    • Biology, Medicine
    • Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
    • 2004
    • 268
    • Highly Influential
    • PDF
    Chemotherapy for the systemic mycoses: the prelude to ketoconazole.
    • J. Utz
    • Medicine
    • Reviews of infectious diseases
    • 1980
    • 18
    Liver injury associated with ketoconazole: Review of the published evidence
    • 41
    Clinical Pharmacokinetics of Ketoconazole
    • 190
    Overview of medically important antifungal azole derivatives.
    • R. Fromtling
    • Biology, Medicine
    • Clinical Microbiology Reviews
    • 1988
    • 306
    • PDF
    Hepatic reactions associated with ketoconazole in the United Kingdom.
    • 140
    • PDF