The Rise and Fall of Oral Ketoconazole

  title={The Rise and Fall of Oral Ketoconazole},
  author={A. Gupta and Danika C A Lyons},
  journal={Journal of Cutaneous Medicine and Surgery},
  pages={352 - 357}
  • A. Gupta, Danika C A Lyons
  • Published 2015
  • Medicine
  • Journal of Cutaneous Medicine and Surgery
  • Background: Ketoconazole was the first broad-spectrum oral antifungal agent available to treat systemic and superficial mycoses. Evidence of hepatotoxicity associated with its use emerged within the first few years of its approval. Growing evidence of serious side effects including endocrine dysregulation, several drug interactions, and death led to the review of oral ketoconazole in 2011. Objective: This article chronicles the use of oral ketoconazole from its introduction to its near… CONTINUE READING

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