The Ribosomal Protein S19 Suppresses Antitumor Immune Responses via the Complement C5a Receptor 1.

@article{Markiewski2017TheRP,
  title={The Ribosomal Protein S19 Suppresses Antitumor Immune Responses via the Complement C5a Receptor 1.},
  author={Maciej M Markiewski and Surya Kumari Vadrevu and Sharad K Sharma and Navin Kumar Chintala and Shanawaz Ghouse and Jun-Hung Cho and David P. Fairlie and Yvonne Paterson and Aristotelis Astrinidis and Magdalena Karbowniczek},
  journal={Journal of immunology},
  year={2017},
  volume={198 7},
  pages={2989-2999}
}
Relatively little is known about factors that initiate immunosuppression in tumors and act at the interface between tumor cells and host cells. In this article, we report novel immunosuppressive properties of the ribosomal protein S19 (RPS19), which is upregulated in human breast and ovarian cancer cells and released from apoptotic tumor cells, whereupon it interacts with the complement C5a receptor 1 expressed on tumor infiltrating myeloid-derived suppressor cells. This interaction promotes… CONTINUE READING
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