The Rhoptry Pseudokinase ROP54 Modulates Toxoplasma gondii Virulence and Host GBP2 Loading

@inproceedings{Kim2016TheRP,
  title={The Rhoptry Pseudokinase ROP54 Modulates Toxoplasma gondii Virulence and Host GBP2 Loading},
  author={Elliot W. Kim and Santhosh M. Nadipuram and Ashley L. Tetlow and William D. Barshop and Philip T Liu and James A Wohlschlegel and Peter J. Bradley},
  booktitle={mSphere},
  year={2016}
}
Toxoplasma gondii uses unique secretory organelles called rhoptries to inject an array of effector proteins into the host cytoplasm that hijack host cell functions. We have discovered a novel rhoptry pseudokinase effector, ROP54, which is injected into the host cell upon invasion and traffics to the cytoplasmic face of the parasitophorous vacuole membrane (PVM). Disruption of ROP54 in a type II strain of T. gondii does not affect growth in vitro but results in a 100-fold decrease in virulence… CONTINUE READING
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