The Rhodococcus equi virulence protein VapA disrupts endolysosome function and stimulates lysosome biogenesis

@inproceedings{Rofe2017TheRE,
  title={The Rhodococcus equi virulence protein VapA disrupts endolysosome function and stimulates lysosome biogenesis},
  author={Adam P. Rofe and Luther J. Davis and Jean L. Whittingham and Elizabeth C. Latimer‐Bowman and Anthony James Wilkinson and Paul R Pryor},
  booktitle={MicrobiologyOpen},
  year={2017}
}
Rhodococcus equi (R. equi) is an important pulmonary pathogen in foals that often leads to the death of the horse. The bacterium harbors a virulence plasmid that encodes numerous virulence-associated proteins (Vaps) including VapA that is essential for intracellular survival inside macrophages. However, little is known about the precise function of VapA. Here, we demonstrate that VapA causes perturbation to late endocytic organelles with swollen endolysosome organelles having reduced Cathepsin… CONTINUE READING

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