The RhoGEF DOCK10 is essential for dendritic spine morphogenesis

  title={The RhoGEF DOCK10 is essential for dendritic spine morphogenesis},
  author={Fanny Jaudon and Fabrice Raynaud and Rosine Wehrl{\'e} and Jean-Michel Bellanger and Mohamed Doulazmi and Guilan Vodjdani and St{\'e}phane Gasman and Laurent Fagni and Isabelle Dusart and Anne Debant and Susanne I. Schmidt and Kozo Kaibuchi},
  booktitle={Molecular biology of the cell},
By regulating actin cytoskeleton dynamics, Rho GTPases and their activators RhoGEFs are implicated in various aspects of neuronal differentiation, including dendritogenesis and synaptogenesis. Purkinje cells (PCs) of the cerebellum, by developing spectacular dendrites covered with spines, represent an attractive model system in which to decipher the molecular signaling underlying these processes. To identify novel regulators of dendritic spine morphogenesis among members of the poorly… CONTINUE READING
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