The RhoGAP Domain of CYK-4 Has an Essential Role in RhoA Activation

@article{Loria2012TheRD,
  title={The RhoGAP Domain of CYK-4 Has an Essential Role in RhoA Activation},
  author={Andy Loria and Katrina Marie Longhini and Michael Glotzer},
  journal={Current Biology},
  year={2012},
  volume={22}
}
Cytokinesis in animal cells is mediated by a cortical actomyosin-based contractile ring. The GTPase RhoA is a critical regulator of this process as it activates both nonmuscle myosin and a nucleator of actin filaments [1]. The site at which active RhoA and its effectors accumulate is controlled by the microtubule-based spindle during anaphase [2]. ECT-2, the guanine nucleotide exchange factor (GEF) that activates RhoA during cytokinesis, is regulated by phosphorylation and subcellular… CONTINUE READING

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CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis

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