The Rho1 effector Pkc1, but not Bni1, mediates signalling from Tor2 to the actin cytoskeleton

@article{Helliwell1998TheRE,
  title={The Rho1 effector Pkc1, but not Bni1, mediates signalling from Tor2 to the actin cytoskeleton},
  author={Stephen B Helliwell and Anja S Schmidt and Yoshikazu Ohya and Michael N. Hall},
  journal={Current Biology},
  year={1998},
  volume={8},
  pages={1211-S2}
}
In Saccharomyces cerevisiae, the phosphatidylinositol kinase homologue Tor2 controls the cell-cycle-dependent organisation of the actin cytoskeleton by activating the small GTPase Rho1 via the exchange factor Rom2 [1,2]. Four Rho1 effectors are known, protein kinase C 1 (Pkc1), the formin-family protein Bni1, the glucan synthase Fks and the signalling protein Skn7 [2,3]. Rho1 has been suggested to signal to the actin cytoskeleton via Bni1 and Pkc1; rho1 mutants have never been shown to have… CONTINUE READING

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