The Rho kinase inhibitor SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries.

@article{Grisk2012TheRK,
  title={The Rho kinase inhibitor SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries.},
  author={Olaf Grisk and Torsten Schl{\"u}ter and Nico Reimer and Uwe Zimmermann and Elpiniki Katsari and Oliver Plettenburg and Matthias Loehn and Hans-Georg Wollert and Rainer Rettig},
  journal={Journal of hypertension},
  year={2012},
  volume={30 5},
  pages={980-9}
}
OBJECTIVES Increased renal vascular resistance contributes to the pathogenesis of hypertension. The new Rho kinase (ROCK) inhibitor SAR407899 more potently lowers arterial pressure than the commercially available ROCK inhibitor Y27623. We tested whether ROCK inhibition more effectively reduced agonist-induced vasoconstriction in renal than in nonrenal… CONTINUE READING