The Rho GTPase Cdc42 is required for primary mammary epithelial cell morphogenesis in vitro.

@article{Bray2011TheRG,
  title={The Rho GTPase Cdc42 is required for primary mammary epithelial cell morphogenesis in vitro.},
  author={Kristi Bray and Cord Brakebusch and Tracy Vargo-Gogola},
  journal={Small GTPases},
  year={2011},
  volume={2 5},
  pages={247-258}
}
The Rho GTPase Cdc42 is overexpressed and hyperactivated in breast cancer, and several studies have described mechanisms by which it may promote tumor formation and progression. However, little is known about the role of Cdc42 during normal mammary epithelial cell (MEC) morphogenesis. Here we aimed to define the precise role for Cdc42 during primary mammary acinus formation in vitro. For these studies, MECs were isolated from Cdc42fl/fl conditional knockout mice, transduced with Adeno-cre-GFP… CONTINUE READING
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