The Rhizobium leguminosarum regulator IrrA affects the transcription of a wide range of genes in response to Fe availability

@article{Todd2006TheRL,
  title={The Rhizobium leguminosarum regulator IrrA affects the transcription of a wide range of genes in response to Fe availability},
  author={Jonathan D. Todd and Gary Sawers and Dmitry A. Rodionov and Andrew W. B. Johnston},
  journal={Molecular Genetics and Genomics},
  year={2006},
  volume={275},
  pages={564-577}
}
We show that an unusual transcriptional regulator, called IrrA, regulates many genes in the symbiotic N2-fixing bacterium Rhizobium leguminosarum in response to iron availability. Several operons in R. leguminosarum are expressed at lower levels in cells grown in Fe-depleted compared to Fe-replete medium. These include hemA1, which encodes the haem biosynthesis enzyme amino-levulinic acid synthase; sufS2BCDS1XA, which specify enzymes for FeS cluster synthesis; rirA, a global, Fe-responsive… CONTINUE READING

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GenBank

  • DA Benson, I Karsch-Mizrachi, DJ Lipman, J Ostell, DL Wheeler
  • Nucleic Acids Res
  • 2005
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