The Retromer Coat Complex Coordinates Endosomal Sorting and Dynein-Mediated Transport, with Carrier Recognition by the trans-Golgi Network

@inproceedings{Wassmer2009TheRC,
  title={The Retromer Coat Complex Coordinates Endosomal Sorting and Dynein-Mediated Transport, with Carrier Recognition by the trans-Golgi Network},
  author={Thomas Wassmer and Naomi Attar and Martin Harterink and Jan R. T. van Weering and Colin J. Traer and Jacqueline Oakley and Bruno Goud and David J Stephens and Paul Verkade and Hendrik C. Korswagen and Peter J. Cullen},
  booktitle={Developmental cell},
  year={2009}
}
Early endosome-to-trans-Golgi network (TGN) transport is organized by the retromer complex. Consisting of cargo-selective and membrane-bound subcomplexes, retromer coordinates sorting with membrane deformation and carrier formation. Here, we describe four mammalian retromers whose membrane-bound subcomplexes contain specific combinations of the sorting nexins (SNX), SNX1, SNX2, SNX5, and SNX6. We establish that retromer requires a dynamic spatial organization of the endosomal network, which is… CONTINUE READING
Highly Influential
This paper has highly influenced 15 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS