# The Retinal Inner Plexiform Synaptic Layer Mirrors Grey Matter Thickness of Primary Visual Cortex with Increased Amyloid β Load in Early Alzheimer's Disease

@article{Jorge2020TheRI,
title={The Retinal Inner Plexiform Synaptic Layer Mirrors Grey Matter Thickness of Primary Visual Cortex with Increased Amyloid $\beta$ Load in Early Alzheimer's Disease},
author={L{\'i}lia Jorge and N{\'a}dia Can{\'a}rio and Ricardo Martins and Beatriz Santiago and Isabel Santana and Hugo Quental and Francisco Rosa Gomes Ambr{\'o}sio and Rui Bernardes and Miguel Castelo‐Branco},
journal={Neural Plasticity},
year={2020},
volume={2020}
}
• Published 21 September 2020
• Biology
• Neural Plasticity
The retina may serve as putative window into neuropathology of synaptic loss in Alzheimer's disease (AD). Here, we investigated synapse-rich layers versus layers composed by nuclei/cell bodies in an early stage of AD. In addition, we examined the associations between retinal changes and molecular and structural markers of cortical damage. We recruited 20 AD patients and 17 healthy controls (HC). Combining optical coherence tomography (OCT), magnetic resonance (MR), and positron emission…
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## References

SHOWING 1-10 OF 111 REFERENCES

### The Association Between Retinal Neuronal Layer and Brain Structure is Disrupted in Patients with Cognitive Impairment and Alzheimer's Disease.

• Biology, Psychology
Journal of Alzheimer's disease : JAD
• 2016
The findings suggest the possible physiological retina-brain relationship in healthy aging, which might be disrupted by disease-induced changes in patients with cognitive impairment, which should be confirmed by longitudinal study with larger patient sample.

### Retinal ganglion cell analysis using high-definition optical coherence tomography in patients with mild cognitive impairment and Alzheimer's disease.

• Biology, Medicine
Journal of Alzheimer's disease : JAD
• 2015
The data strengthens the link between retinal ganglion cell neuronal and optic nerve axonal loss with AD, and suggests that assessment of macular GC-IPL can be a test to detect neuronal injury in early AD and MCI.

### Retinal nerve fiber layer thinning in dementia associated with Parkinson's disease, dementia with Lewy bodies, and Alzheimer's disease.

• Medicine, Psychology
Journal of Alzheimer's disease : JAD
• 2013
The findings from this study show that retinal involvement measured by optical coherence tomography may also be present in non-AD dementias.

### Relationship between Cognitive Impairment and Retinal Morphological and Visual Functional Abnormalities in Alzheimer Disease

• Medicine
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
• 2006
This study confirms some other studies in showing that in AD patients there is a reduction of parapapillary and macular RNFL thickness and Macular volume as measured by OCT, and this reduction was related to the severity of cognitive impairment.

### Optical Coherence Tomography in Alzheimer’s Disease: A Meta-Analysis

• Medicine, Biology
PloS one
• 2015
An aggregate meta-analysis combining results from different studies that examined the RNFL thickness by means of OCT in AD and MCI patients compared with cognitively healthy controls supports the important role of OCT for RNFL analysis in monitoring the progression of AD and in assessing the effectiveness of purported AD treatments.

### Is the Retina a Mirror of the Aging Brain? Aging of Neural Retina Layers and Primary Visual Cortex Across the Lifespan

• Medicine, Biology
Frontiers in Aging Neuroscience
• 2019
An age-related decay of primary visual cortical thickness that was significantly correlated with a decrease in global and multiple layer retinal thicknesses was found and associations with other cortical regions suggest that retinal status may index cortical integrity in general.