The Retinal Inner Plexiform Synaptic Layer Mirrors Grey Matter Thickness of Primary Visual Cortex with Increased Amyloid β Load in Early Alzheimer's Disease

  title={The Retinal Inner Plexiform Synaptic Layer Mirrors Grey Matter Thickness of Primary Visual Cortex with Increased Amyloid $\beta$ Load in Early Alzheimer's Disease},
  author={L{\'i}lia Jorge and N{\'a}dia Can{\'a}rio and Ricardo Martins and Beatriz Santiago and Isabel Santana and Hugo Quental and Francisco Rosa Gomes Ambr{\'o}sio and Rui Bernardes and Miguel Castelo‐Branco},
  journal={Neural Plasticity},
The retina may serve as putative window into neuropathology of synaptic loss in Alzheimer's disease (AD). Here, we investigated synapse-rich layers versus layers composed by nuclei/cell bodies in an early stage of AD. In addition, we examined the associations between retinal changes and molecular and structural markers of cortical damage. We recruited 20 AD patients and 17 healthy controls (HC). Combining optical coherence tomography (OCT), magnetic resonance (MR), and positron emission… 

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