The Responses of Mouse Preimplantation Embryos to Leptin In Vitro in a Transgenerational Model for Obesity

@inproceedings{Kianov2017TheRO,
  title={The Responses of Mouse Preimplantation Embryos to Leptin In Vitro in a Transgenerational Model for Obesity},
  author={Martina K{\vs}iňanov{\'a} and {\vS}tefan {\vC}{\'i}ko{\vs} and Janka Babel’ov{\'a} and Zuzana {\vS}ef{\vc}{\'i}kov{\'a} and Alexandra {\vS}pirkov{\'a} and Juraj Koppel and Du{\vs}an Fabian},
  booktitle={Front. Endocrinol.},
  year={2017}
}
The aim of the present study was to test the hypothesis that leptin can directly mediate the negative effect of maternal obesity on preimplantation embryos. As previously shown, maternal obesity retards early embryonic development in vivo and increases the incidence of apoptosis in blastocysts. When two-cell embryos isolated from control and obese mice were… CONTINUE READING