The Response of the Metabolic Network of the Red Blood Cell to Pyruvate Kinase Deficiency

The response of the metabolic network of human red blood cell is investigated using the E-Cell simulation system when pyruvate kinase (PK) is deficient. The results that several downstream metabolites of the glycolysis pathway accumulate are in a good agreement with experimental data reported in literatures. This accumulation results in the reaction that… CONTINUE READING