The Replisome-Coupled E3 Ubiquitin Ligase Rtt101Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress

@inproceedings{Buser2016TheRE,
  title={The Replisome-Coupled E3 Ubiquitin Ligase Rtt101Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress},
  author={Raymond Buser and Vanessa Kellner and Andre Melnik and Caroline Wilson-Zbinden and Ren{\'e} Schellhaas and Lisa Kastner and Wojciech Piwko and Martina Dees and Paola Picotti and Marija Maric and Karim Labib and Brian Luke and Matthias Peter and Judith L. Campbell},
  booktitle={PLoS genetics},
  year={2016}
}
Faithful DNA replication and repair requires the activity of cullin 4-based E3 ubiquitin ligases (CRL4), but the underlying mechanisms remain poorly understood. The budding yeast Cul4 homologue, Rtt101, in complex with the linker Mms1 and the putative substrate adaptor Mms22 promotes progression of replication forks through damaged DNA. Here we characterized the interactome of Mms22 and found that the Rtt101(Mms22) ligase associates with the replisome progression complex during S-phase via the… CONTINUE READING
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