The Repertoire of G-Protein–Coupled Receptors in Fully Sequenced Genomes

  title={The Repertoire of G-Protein–Coupled Receptors in Fully Sequenced Genomes},
  author={Robert Fredriksson and Helgi Birgir Schi{\"o}th},
  journal={Molecular Pharmacology},
  pages={1414 - 1425}
The superfamily of G-protein–coupled receptors (GPCRs) is one of the largest and most studied families of proteins. We created Hidden Markov Models derived from sorted groups of GPCRs from our previous detailed phylogenetic classification of human GPCRs and added several other models derived from receptors not found in mammals. We used these models to search entire Genscan data sets from 13 species whose genomes are nearly completely sequenced. We found more than 5000 unique GPCRs that were… 

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