The Rep 52 Gene Product of Adeno-Associated Virus Is a DNA Helicase with 3 9-to-5 9 Polarity

@inproceedings{Smith1998TheR5,
  title={The Rep 52 Gene Product of Adeno-Associated Virus Is a DNA Helicase with 3 9-to-5 9 Polarity},
  author={Richard H. Smith and Robert M. Kotin},
  year={1998}
}
The rep gene of adeno-associated virus type 2 encodes four overlapping proteins from two separate promoters, termed P5 and P19. The P5-promoted Rep proteins, Rep78 and Rep68, are essential for viral DNA replication, and a wealth of data concerning the biochemical activities of these proteins has been reported. In contrast, data concerning the biochemical functions of the P19-promoted Rep proteins, Rep52 and Rep40, are lacking. Here, we describe enzymatic activities associated with a bacterially… CONTINUE READING