The Relative Roles of Passive Surface Forces and Active Ion Transport in the Modulation of Airway Surface Liquid Volume and Composition

@article{Tarran2001TheRR,
  title={The Relative Roles of Passive Surface Forces and Active Ion Transport in the Modulation of Airway Surface Liquid Volume and Composition},
  author={Robert Tarran and Barbara R. Grubb and John T. Gatzy and Christiana W Davis and Richard C. Boucher},
  journal={The Journal of General Physiology},
  year={2001},
  volume={118},
  pages={223 - 236}
}
Two hypotheses have been proposed recently that offer different views on the role of airway surface liquid (ASL) in lung defense. The "compositional" hypothesis predicts that ASL [NaCl] is kept low (<50 mM) by passive forces to permit antimicrobial factors to act as a chemical defense. The "volume" hypothesis predicts that ASL volume (height) is regulated isotonically by active ion transport to maintain efficient mechanical mucus clearance as the primary form of lung defense. To compare these… CONTINUE READING