The Relative Contribution of Monoamine Oxidase and Cytochrome P450 Isozymes to the Metabolic Deamination of the Trace Amine Tryptamine

@article{Yu2003TheRC,
  title={The Relative Contribution of Monoamine Oxidase and Cytochrome P450 Isozymes to the Metabolic Deamination of the Trace Amine Tryptamine},
  author={Ai-Ming Yu and Camille P. Granvil and Robert L Haining and Kristopher W. Krausz and J. Rodr{\'i}guez Corchero and Adrian K{\"u}pfer and Jeffrey R. Idle and Frank J. Gonzalez},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2003},
  volume={304},
  pages={539 - 546}
}
Tryptamine is a trace amine in mammalian central nervous system that interacts with the trace amine TA2 receptor and is now thought to function as a neurotransmitter or neuromodulator. It had been reported that deamination of tryptamine to tryptophol was mediated by CYP2D6, a cytochrome P450 that is expressed in human brain, suggesting that tryptamine may be an endogenous substrate for this polymorphic enzyme. We were unable to confirm this report and have reinvestigated tryptamine metabolism… Expand
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