The Relationships between Thyroid Hormones and the Brain Serotonin (5-HT) System and Mood: Of Synergy and Significance in the Adult Brain- A Review

  title={The Relationships between Thyroid Hormones and the Brain Serotonin (5-HT) System and Mood: Of Synergy and Significance in the Adult Brain- A Review},
  author={Hafizur Rahman and Yusuf Ali},
  journal={Faridpur Medical College Journal},
  • H. Rahman, Y. Ali
  • Published 12 November 2015
  • Medicine
  • Faridpur Medical College Journal
The use of thyroid hormones as an effective adjunct treatment for affective disorders has been studied over the past three decades and has been conformed repeatedly. Interaction of the thyroid and monoamine neurotransmitter systems has been suggested as a potential underline mechanism of action. While catecholamine and thyroid interrelationships have been reviewed in detail, the serotonin system has been relatively neglected. Thus, the goal of this article is to review the literature on the… 
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The hypothesis is offered that the thyroid hormones influence affective state via postreceptor mechanisms that facilitate signal transduction pathways in the adult mammalian brain, generalizable to widely recognized targets of antidepressant therapies such as noradrenergic and serotonergic neurotransmission.
Thyroid Hormone, Neural Tissue and Mood Modulation
  • M. Bauer, P. Whybrow
  • Psychology, Medicine
    The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
  • 2001
There is good evidence that triiodothyronine (T3) may accelerate the antidepressant response to tricylic antidepressants, and some studies suggest that T3 may augment the therapeutic response to antidepressants in refractory depressed patients.
A hypothesis of thyroid-catecholamine-receptor interaction. Its relevance to affective illness.
Evidence suggests that the modulation by thyroid hormones of the beta-adrenergic receptor response to catecholamines may contribute to these effects of depression and mania.
Thyroid hormone control of serotonin in developing rat brain.
The data suggest that thyroid hormone may exert an important regulatory influence on serotonin metabolism in the developing brain.
The biochemistry of affective disorders.
  • A. Coppen
  • Psychology, Medicine
    The British journal of psychiatry : the journal of mental science
  • 1967
It might be envisaged that alterations in the electrolyte distribution could produce two changes in the brain: a direct change in excitability of neurones and a change in the production of monoamines, such as 5-hydroxytryptamine, which are presumably used to "modulate" synaptic transmission.
Peripheral Indices of Central Serotonin Function in Humans
  • D. Murphy
  • Medicine
    Annals of the New York Academy of Sciences
  • 1990
Serotonin (5-HT), its metabolites, and some of its metabolic processes which are accessible outside of brain or spinal cord tissue have been evaluated as potential peripheral indices of the
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