The Relationship between Plasminogen Activator Inhibitor-1 and Proinflammatory and Counterinflammatory Mediators in Children with Meningococcal Septic Shock

@article{Kornelisse1996TheRB,
  title={The Relationship between Plasminogen Activator Inhibitor-1 and Proinflammatory and Counterinflammatory Mediators in Children with Meningococcal Septic Shock},
  author={Ren{\'e} F. Kornelisse and Jan A. Hazelzet and Huub F J Savelkoul and Wim C. J. Hop and Marja H. Suur and Alexander N. J. Borsboom and Inge M. Risseeuw-Appel and Edwin van der Voort and Ronald de Groot},
  journal={The Journal of infectious diseases},
  year={1996},
  volume={173 5},
  pages={
          1148-56
        }
}
Proinflammatory cytokines (tumor necrosis factor [TNF]-alpha and interleukin [IL]-6 and -8), counterinflammatory compounds (IL-10 and soluble TNF receptors p55 and p75 [sTNFR-55 and -75]), and hemostatic parameters were determined in 38 patients with meningococcal septic shock. Eleven patients (29%) died. Serum levels of pro- and counterinflammatory compounds and plasma levels of plasminogen activator inhibitor (PAI)-1 were significantly higher in nonsurvivors. The interval between appearance… CONTINUE READING
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