The Relationship between Antigenic Structure and the Requirement for Thymus-derived Cells in the Immune Response

@article{Feldmann1971TheRB,
  title={The Relationship between Antigenic Structure and the Requirement for Thymus-derived Cells in the Immune Response},
  author={Marc Feldmann and Antony Basten},
  journal={The Journal of Experimental Medicine},
  year={1971},
  volume={134},
  pages={103 - 119}
}
Certain antigens such as polymerized flagellin are capable of producing relatively normal antibody levels in thymectomized mice, whereas others, including heterologous erythrocytes require the presence of T cells in a helper capacity. The mechanism of thymus-independent antibody production was investigated by comparing the primary IgM responses of spleen cells from ATXBM, XBM, and normal mice to various physical forms of the flagellar antigens of Salmonella adelaide in vitro. No reduction in… CONTINUE READING

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