The Relationship Between Rat Intestinal Permeability and Hydrophilic Probe Size

Abstract

Purpose. The relationship between rat intestinal permeability (Papp) of a range of hydrophilic probe molecules and probe geometry was examined. Methods. Molecules studied included mannitol, the polyethylene glycols (PEGs) 400, 900, and 4000, the dextran conjugated dye Texas Red® (MW 3000) and the polysaccharide inulin (MW 5500). Molecular surface area… (More)
DOI: 10.1023/A:1016091915733

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