The Relationship Between Polycystic Ovary Syndrome and Antiepileptic Drugs: A Review of the Evidence

  title={The Relationship Between Polycystic Ovary Syndrome and Antiepileptic Drugs: A Review of the Evidence},
  author={Natalie L. Rasgon},
  journal={Journal of Clinical Psychopharmacology},
  • N. Rasgon
  • Published 1 June 2004
  • Medicine, Psychology
  • Journal of Clinical Psychopharmacology
Abstract: Polycystic ovary syndrome (PCOS) is a serious endocrine disorder characterized by ovulatory dysfunction and hyperandrogenism that is thought to have a higher prevalence in women with epilepsy and perhaps bipolar disorder. Various theories have been offered to explain this higher prevalence of PCOS and other reproductive disorders in these patient populations, including the effects of the disease itself and of antiepileptic drugs, especially valproate, which may directly cause PCOS or… 


An overview of pathogenesis, symptoms, treatment strategy and some novel targets of PCOS has been presented in this paper.

Endocrine reproductive dysfunctions in women with epilepsy on antiepileptic therapy

The endocrine - reproductive dysfunctions occurred more frequently in epileptic women treated with valproate; these endocrine abnormalities may have a negative impact on fertility in women with epilepsy and therefore young patients should be screened and carefully evaluated in an endocrinology service prior to start the anti- epileptic treatment.

Polycystic Ovarian Syndrome (PCOS)

An overview of the workup and diagnostic criteria for PCOS in adolescents is provided, and strategies for nutritional assessment, diagnosis and management are reviewed.

Current aspects of polycystic ovary syndrome I: definition, pathophysiology, clinical manifestations, diagnosis and complications

The role of genetically determined hyperandrogenism, that of insulin resistance-hyperinsulinism and the importance of reinforcing each other are emphasized and the effects of the mentioned pathological processes on the endocrine and other organ structures participating in the regulation of sexual functions are discussed.

Etiological Role of Environmental Toxicants in Polycystic Ovarian Syndrome

Polycystic ovary syndrome (PCOS) is termed as the most common and complex reproductive and metabolic disorder, marked by increased androgen levels, irregularities in the menstrual cycle, and/ or

Polycystic Ovary Syndrome and Mental Health: A Review

It is indicated that PCOS is associated with several mental health problems, including depression and anxiety, body dissatisfaction and eating disorders, diminished sexual satisfaction, and lowered health-related quality of life.

Epilepsy, sex hormones and antiepileptic drugs in female patients

The aim of the present review is to critically evaluate the recently published data concerning the interactions between sex hormones, epilepsy and AEDs.

Antiepileptic drugs, sex hormones, and PCOS

The use of the liver enzyme–inducing AEDs—such as phenobarbital, phenytoin, and carbamazepine—can increase serum sex hormone–binding globulin concentrations, leading to diminished bioactivity of testosterone (T) and estradiol.



Medication status and polycystic ovary syndrome in women with bipolar disorder: a preliminary report.

In this pilot study of bipolar patients, PCO-like changes were not seen in women receiving divalproex or lithium, suggesting that the hypothalamic-pituitary-gonadal axis may be compromised in some women with bipolar disorder.

Polycystic ovarian syndrome: the metabolic syndrome comes to gynaecology

This article focuses on the recent change in attitudes to polycystic ovarian syndrome arising from the link with insulin resistance—a concept that not only has major implications for the health of affected women but also offers a potential for new treatments.

Phenotype and genotype in polycystic ovary syndrome.

It is suggested that hyperandrogenism in females and glucose intolerance may be genetic traits in PCOS kindreds.

The Importance of Diagnosing the Polycystic Ovary Syndrome

In women who present with hyperandrogenism and chronic anovulation, a diagnosis of PCOS is considered reasonable after other endocrine disorders have been ruled out.

Polycystic ovary syndrome and cancer.

  • A. Balen
  • Medicine
    Human reproduction update
  • 2001
The polycystic ovary syndrome (PCOS) is the most common endocrine disturbance affecting women, but disagreements in diagnostic criteria make it difficult to compare epidemiological studies on

Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy.

Menstrual disturbances, polycystic ovaries, and hyperandrogenism are often encountered in women taking valproate for epilepsy.

Menstrual abnormalities and polycystic ovary syndrome in women taking valproate for bipolar mood disorder.

These results suggest high rates of menstrual disturbances and polycystic ovary syndrome in women with bipolar disorder currently receiving valproate.

Characterization of reproductive endocrine disorders in women with epilepsy.

The results of this study suggest that the prevalence of disordered ovulation, in particular polycystic ovary syndrome, is increased in epilepsy, independent of antiepileptic medications or type of seizure disorder.

Current concepts of polycystic ovary syndrome.

  • R. Rosenfield
  • Medicine, Biology
    Bailliere's clinical obstetrics and gynaecology
  • 1997
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