The Relationship Between Polycystic Ovary Syndrome and Antiepileptic Drugs: A Review of the Evidence

@article{Rasgon2004TheRB,
  title={The Relationship Between Polycystic Ovary Syndrome and Antiepileptic Drugs: A Review of the Evidence},
  author={Natalie Rasgon},
  journal={Journal of Clinical Psychopharmacology},
  year={2004},
  volume={24},
  pages={322-334}
}
  • N. Rasgon
  • Published 1 June 2004
  • Medicine
  • Journal of Clinical Psychopharmacology
Abstract: Polycystic ovary syndrome (PCOS) is a serious endocrine disorder characterized by ovulatory dysfunction and hyperandrogenism that is thought to have a higher prevalence in women with epilepsy and perhaps bipolar disorder. Various theories have been offered to explain this higher prevalence of PCOS and other reproductive disorders in these patient populations, including the effects of the disease itself and of antiepileptic drugs, especially valproate, which may directly cause PCOS or… Expand
Genetic overlap between polycystic ovary syndrome and bipolar disorder: the endophenotype hypothesis.
TLDR
It is postulates that shared clinical endophenotypes between PCOS and BD indicate common pathophysiological platforms and will review these for the potential of genetic overlap between the two disorders. Expand
Polycystic Ovarian Syndrome (PCOS)
TLDR
An overview of the workup and diagnostic criteria for PCOS in adolescents is provided, and strategies for nutritional assessment, diagnosis and management are reviewed. Expand
Current aspects of polycystic ovary syndrome I: definition, pathophysiology, clinical manifestations, diagnosis and complications
TLDR
The role of genetically determined hyperandrogenism, that of insulin resistance-hyperinsulinism and the importance of reinforcing each other are emphasized and the effects of the mentioned pathological processes on the endocrine and other organ structures participating in the regulation of sexual functions are discussed. Expand
Polycystic Ovaries and Polycystic Ovary Syndrome in Epilepsy: Evidence for Neurogonadal Disease
TLDR
It is proposed that epilepsy, with its known adverse effects on luteinizing hormone pulsatility, could be a cause of PCOS and that valproate could be an imitator, if not also a cause, of the syndrome. Expand
Etiological Role of Environmental Toxicants in Polycystic Ovarian Syndrome
Polycystic ovary syndrome (PCOS) is termed as the most common and complex reproductive and metabolic disorder, marked by increased androgen levels, irregularities in the menstrual cycle, and/ orExpand
Polycystic Ovary Syndrome and Mental Health: A Review
TLDR
It is indicated that PCOS is associated with several mental health problems, including depression and anxiety, body dissatisfaction and eating disorders, diminished sexual satisfaction, and lowered health-related quality of life. Expand
Epilepsy, sex hormones and antiepileptic drugs in female patients
TLDR
The aim of the present review is to critically evaluate the recently published data concerning the interactions between sex hormones, epilepsy and AEDs. Expand
Antiepileptic drugs, sex hormones, and PCOS
TLDR
The use of the liver enzyme–inducing AEDs—such as phenobarbital, phenytoin, and carbamazepine—can increase serum sex hormone–binding globulin concentrations, leading to diminished bioactivity of testosterone (T) and estradiol. Expand
Current issues: women and bipolar disorder
TLDR
Treatment of women with bipolar disorder is even more challenging because clinicians must also individualize treatment based on the potential for pregnancy, drug interactions with oral contraceptives, and an increased risk of endocrine diseases that can either impact the course of illness or become manifest with some treatments. Expand
Incidence of polycystic ovaries and androgen serum levels in women with borderline personality disorder.
TLDR
The data suggest a disturbed androgen metabolism in BPD patients, and testosterone, FT, androstenedione, and 17alpha-hydroxyprogesterone (17-OHP) were significantly elevated in the BPD group independently of BMI. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 88 REFERENCES
Medication status and polycystic ovary syndrome in women with bipolar disorder: a preliminary report.
TLDR
In this pilot study of bipolar patients, PCO-like changes were not seen in women receiving divalproex or lithium, suggesting that the hypothalamic-pituitary-gonadal axis may be compromised in some women with bipolar disorder. Expand
Polycystic ovarian syndrome: the metabolic syndrome comes to gynaecology
TLDR
This article focuses on the recent change in attitudes to polycystic ovarian syndrome arising from the link with insulin resistance—a concept that not only has major implications for the health of affected women but also offers a potential for new treatments. Expand
Phenotype and genotype in polycystic ovary syndrome.
TLDR
It is suggested that hyperandrogenism in females and glucose intolerance may be genetic traits in PCOS kindreds. Expand
The Importance of Diagnosing the Polycystic Ovary Syndrome
TLDR
In women who present with hyperandrogenism and chronic anovulation, a diagnosis of PCOS is considered reasonable after other endocrine disorders have been ruled out. Expand
Polycystic ovary syndrome in patients with focal epilepsy: a study in 93 women
TLDR
The results of this study suggest that the manifestation of PCOS in women with focal epilepsy is not related to the administration of valproate or carbamazepine. Expand
Polycystic ovary syndrome and cancer.
  • A. Balen
  • Medicine
  • Human reproduction update
  • 2001
The polycystic ovary syndrome (PCOS) is the most common endocrine disturbance affecting women, but disagreements in diagnostic criteria make it difficult to compare epidemiological studies onExpand
Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy.
TLDR
Menstrual disturbances, polycystic ovaries, and hyperandrogenism are often encountered in women taking valproate for epilepsy. Expand
Menstrual abnormalities and polycystic ovary syndrome in women taking valproate for bipolar mood disorder.
TLDR
These results suggest high rates of menstrual disturbances and polycystic ovary syndrome in women with bipolar disorder currently receiving valproate. Expand
Characterization of reproductive endocrine disorders in women with epilepsy.
TLDR
The results of this study suggest that the prevalence of disordered ovulation, in particular polycystic ovary syndrome, is increased in epilepsy, independent of antiepileptic medications or type of seizure disorder. Expand
Current concepts of polycystic ovary syndrome.
  • R. Rosenfield
  • Medicine
  • Bailliere's clinical obstetrics and gynaecology
  • 1997
TLDR
PCOS should be viewed as an early manifestation of a hyperinsulinaemic condition that will predispose to cardiovascular and metabolic complications later in life, and a subset of PCOS patients appear to have not only insulin resistance but also beta-cell secretory dysfunction, which may indicate a relationship of the disorder to NIDDM. Expand
...
1
2
3
4
5
...