The Relationship Between Polycystic Ovary Syndrome and Antiepileptic Drugs: A Review of the Evidence

@article{Rasgon2004TheRB,
  title={The Relationship Between Polycystic Ovary Syndrome and Antiepileptic Drugs: A Review of the Evidence},
  author={Natalie L. Rasgon},
  journal={Journal of Clinical Psychopharmacology},
  year={2004},
  volume={24},
  pages={322-334}
}
  • N. Rasgon
  • Published 1 June 2004
  • Medicine, Psychology
  • Journal of Clinical Psychopharmacology
Abstract: Polycystic ovary syndrome (PCOS) is a serious endocrine disorder characterized by ovulatory dysfunction and hyperandrogenism that is thought to have a higher prevalence in women with epilepsy and perhaps bipolar disorder. Various theories have been offered to explain this higher prevalence of PCOS and other reproductive disorders in these patient populations, including the effects of the disease itself and of antiepileptic drugs, especially valproate, which may directly cause PCOS or… 

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Epilepsy, sex hormones and antiepileptic drugs in female patients

TLDR
The aim of the present review is to critically evaluate the recently published data concerning the interactions between sex hormones, epilepsy and AEDs.

Antiepileptic drugs, sex hormones, and PCOS

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The use of the liver enzyme–inducing AEDs—such as phenobarbital, phenytoin, and carbamazepine—can increase serum sex hormone–binding globulin concentrations, leading to diminished bioactivity of testosterone (T) and estradiol.
...

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