The Relation Between Symptom Improvement and Gastric Emptying in the Treatment of Diabetic and Idiopathic Gastroparesis

@article{Janssen2013TheRB,
  title={The Relation Between Symptom Improvement and Gastric Emptying in the Treatment of Diabetic and Idiopathic Gastroparesis},
  author={Pieter Janssen and M. Scott Harris and Mike P Jones and Tatsuhiro Masaoka and Ricard Farr{\'e} and Hans T{\"o}rnblom and Lukas Van Oudenhove and Magnus Simr{\'e}n and Jan Tack},
  journal={The American Journal of Gastroenterology},
  year={2013},
  volume={108},
  pages={1382-1391}
}
OBJECTIVES:The relationship between symptom improvement (SI) and acceleration of gastric emptying (GE) for different drugs used in the treatment of idiopathic and diabetic gastroparesis is uncertain. In this paper we examined the study-specific correlations between SI and GE, and we performed a meta-regression analysis of the association across multiple studies.METHODS:The MEDLINE database (1,946 to present) was searched, and only controlled trials or trials with an established effective… 
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This large outpatient cohort suggests that treatment trends move away from prokinetics and focus on symptom-oriented therapy and/or confounding mood disorders.
Prucalopride in Gastroparesis: A Randomized Placebo-Controlled Crossover Study.
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In a cohort of patients with predominantly idiopathic gastroparesis, 4 weeks of prucalopride treatment significantly improved symptoms and quality of life and enhanced gastric emptying compared with placebo.
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High response rates for active and sham interventions indicate that the authors can achieve symptom relief in many patients and thus give them some reassurance, and if indeed most therapies are only marginally better than placebo, the differences in adverse effects should be weighed more strongly.
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