The Rel-associated pp 40 protein prevents DNA binding of Rel and NF-KB : relationship . with IKBI 3 and regulation by phosphorylatlon

@inproceedings{Lawrence2007TheRP,
  title={The Rel-associated pp 40 protein prevents DNA binding of Rel and NF-KB : relationship . with IKBI 3 and regulation by phosphorylatlon},
  author={Lawrence and David James Kerr and Jun-Ichiro Inoue and Nathan S Davis and Egenhard Link and Patrick A. Baeuerle and Henry R. Bose and Inder M Verma},
  year={2007}
}
The product of proto-oncogene Rel associates with a number of cellular proteins. We have studied the effect of one of them, a phosphoprotein of 40 kD (pp40), on the DNA-binding activity of the Rel protein. We demonstrate that purified pp40 not only inhibits the binding of Rel, but also NF-KB (pS0-p65) heterocomplex to DNA. Additionally, IKBI3, but not IKB~, also prevented the binding of Rel to the KB site.. IKB[~ and pp40 are related proteins because (1) they share a number of common tryptic… CONTINUE READING

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