The Reinforcing Properties of Alcohol are Mediated by GABAA1 Receptors in the Ventral Pallidum

@article{June2003TheRP,
  title={The Reinforcing Properties of Alcohol are Mediated by GABAA1 Receptors in the Ventral Pallidum},
  author={Harry L. June and Katrina L. Foster and Peter McKay and Regat A Seyoum and James Edward Woods and Scott C. Harvey and William Joseph Addison Eiler and Collette Grey and Michelle Renee Carroll and Shannan R. McCane and Cecily M. Jones and Wenyuan Yin and Dynesha Mason and Rancia Cummings and M. Carmen Brot{\'o}ns Garc{\'i}a and Chunrong Ma and Prof. S. S. V. N. Sarma and James M Cook and Phil Skolnick},
  journal={Neuropsychopharmacology},
  year={2003},
  volume={28},
  pages={2124-2137}
}
It has been hypothesized that alcohol addiction is mediated, at least in part, by specific γ-aminobutyric acidA (GABAA) receptors within the ventral pallidum (VP). Among the potential GABAA receptor isoforms regulating alcohol-seeking behaviors within the VP, the GABAA α1 receptor subtype (GABAA1) appears pre-eminent. In the present study, we developed β-carboline-3-carboxylate-t-butyl ester (βCCt), a mixed agonist–antagonist benzodiazepine (BDZ) site ligand, with binding selectivity at the A1… CONTINUE READING
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Little evidence of a role for the α1GABAA subunit-containing receptor in a rhesus monkey model of alcohol drinking.

  • Alcoholism, clinical and experimental research
  • 2014
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