The Reinforcing Efficacy of Psychostimulants in Rhesus Monkeys: The Role of Pharmacokinetics and Pharmacodynamics

  title={The Reinforcing Efficacy of Psychostimulants in Rhesus Monkeys: The Role of Pharmacokinetics and Pharmacodynamics},
  author={Joshua A Lile and Zhixia Wang and William L. Woolverton and Jessica E France and Timothy C Gregg and Huw M. L. Davies and Michael A. Nader},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={356 - 366}
  • J. Lile, Zhixia Wang, M. Nader
  • Published 1 October 2003
  • Biology, Chemistry
  • Journal of Pharmacology and Experimental Therapeutics
This study was undertaken to investigate pharmacological variables that influence the reinforcing efficacy of psychostimulants. Rhesus monkeys (n = 9) responded under a within-session, exponentially increasing, progressive ratio schedule of cocaine reinforcement. Doses of cocaine, methylphenidate (MP), cocaine analogs [(±)-2β-propanoyl-3β-(2-naphthyl)-tropane (WF-23), HD-23; (±)-2β-propanoyl-3β-(2-isopropenyl)tropane (WF-60), HD-60; and 2β-propanoyl-3β-(4-tolyl)-tropane (HD-11, WF-11), and 2… 

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