The Regulation of p53 Synthesis

  • Regulace syntézy
  • Published 2012

Abstract

The regulation of p53 expression levels is critical in controlling p53 activity in normal and dama ged cells. This is well illustrated by the E3 ubiquitin ligase MDM2 that targets p53 for proteasomal degradation under normal conditions and is essential for controlling p53 acti­ vity during development. MDM2 is over­expressed in human cancers and together… (More)

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