The Regulation of IGF-1 Gene Transcription and Splicing during Development and Aging

@inproceedings{Oberbauer2013TheRO,
  title={The Regulation of IGF-1 Gene Transcription and Splicing during Development and Aging},
  author={Anita M. Oberbauer},
  booktitle={Front. Endocrinol.},
  year={2013}
}
It is commonly known that the insulin-like growth factor-I gene contains six exons that can be differentially spliced to create multiple transcript variants. Further, there are two mutually exclusive leader exons each having multiple promoter sites that are variably used. The mature IGF-I protein derived from the multiplicity of transcripts does not differ suggesting a regulatory role for the various transcript isoforms. The variant forms possess different stabilities, binding partners, and… CONTINUE READING