The Reduction of EPSC Amplitude in CA1 Pyramidal Neurons by the Peroxynitrite Donor SIN-1 Requires Ca2+ Influx Via Postsynaptic Non-L-Type Voltage Gated Calcium Channels

@article{Zhaowei2013TheRO,
  title={The Reduction of EPSC Amplitude in CA1 Pyramidal Neurons by the Peroxynitrite Donor SIN-1 Requires Ca2+ Influx Via Postsynaptic Non-L-Type Voltage Gated Calcium Channels},
  author={Liu Zhaowei and Xie Yongling and Yang Jiajia and Yang Zhuo},
  journal={Neurochemical Research},
  year={2013},
  volume={39},
  pages={361-371}
}
The peroxynitrite free radical (ONOO−) modulation of miniature excitatory postsynaptic currents (mEPSCs) and spontaneous excitatory postsynaptic currents (sEPSCs) was investigated in rat CA1 pyramidal neurons using the whole-cell patch clamp technique. SIN-1(3-morpholino-sydnonimine), which can lead the simultaneous generation of superoxide anion and nitric oxide, and then form the highly reactive species ONOO−, induced dose-dependent inhibition in amplitudes of both mEPSCs and sEPSCs. The SIN… CONTINUE READING
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