The Reduced Cochlear Output and the Failure to Adapt the Central Auditory Response Causes Tinnitus in Noise Exposed Rats

@inproceedings{Ruettiger2013TheRC,
  title={The Reduced Cochlear Output and the Failure to Adapt the Central Auditory Response Causes Tinnitus in Noise Exposed Rats},
  author={Lukas Ruettiger and Wibke Singer and Rama Panford-Walsh and Masahiro Matsumoto and Sze Chim Lee and Annalisa Zuccotti and Ulrike Zimmermann and Mirko Jaumann and Karin Rohbock and Hao Xiong and Marlies Knipper},
  booktitle={PloS one},
  year={2013}
}
Tinnitus is proposed to be caused by decreased central input from the cochlea, followed by increased spontaneous and evoked subcortical activity that is interpreted as compensation for increased responsiveness of central auditory circuits. We compared equally noise exposed rats separated into groups with and without tinnitus for differences in brain responsiveness relative to the degree of deafferentation in the periphery. We analyzed (1) the number of CtBP2/RIBEYE-positive particles in ribbon… CONTINUE READING
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