The Recurrent Mossy Fiber Pathway of the Epileptic Brain
@article{Nadler2003TheRM, title={The Recurrent Mossy Fiber Pathway of the Epileptic Brain}, author={J. Victor Nadler}, journal={Neurochemical Research}, year={2003}, volume={28}, pages={1649-1658} }
The dentate gyrus is believed to play a key role in the pathogenesis of temporal lobe epilepsy. In normal brain the dentate granule cells serve as a high-resistance gate or filter, inhibiting the propagation of seizures from the entorhinal cortex to the hippocampus. The filtering function of the dentate gyrus depends in part on the near absence of monosynaptic connections among granule cells. In humans with temporal lobe epilepsy and in animal models of temporal lobe epilepsy, dentate granule…
261 Citations
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Computer modelling of the dentate gyrus circuitry and the corresponding structural changes has been used to understand how abnormal mossy fibre sprouting can subserve seizure generation observed in experimental models when epileptogenesis is induced by status epilepticus and suggest that there is a joint action of the compensation theory and Hebbian rules during the inflammatory process that accompanies the status epileptus.
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