The Recurrent Mossy Fiber Pathway of the Epileptic Brain

@article{Nadler2003TheRM,
  title={The Recurrent Mossy Fiber Pathway of the Epileptic Brain},
  author={J. Victor Nadler},
  journal={Neurochemical Research},
  year={2003},
  volume={28},
  pages={1649-1658}
}
  • J. Nadler
  • Published 1 November 2003
  • Biology
  • Neurochemical Research
The dentate gyrus is believed to play a key role in the pathogenesis of temporal lobe epilepsy. In normal brain the dentate granule cells serve as a high-resistance gate or filter, inhibiting the propagation of seizures from the entorhinal cortex to the hippocampus. The filtering function of the dentate gyrus depends in part on the near absence of monosynaptic connections among granule cells. In humans with temporal lobe epilepsy and in animal models of temporal lobe epilepsy, dentate granule… 

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