The Receptors for Mammalian Sweet and Umami Taste

  title={The Receptors for Mammalian Sweet and Umami Taste},
  author={G. Zhao and Y. Zhang and M. Hoon and J. Chandrashekar and I. Erlenbach and N. Ryba and C. Zuker},
  • G. Zhao, Y. Zhang, +4 authors C. Zuker
  • Published 2003
  • Biology, Medicine
  • Cell
  • Sweet and umami (the taste of monosodium glutamate) are the main attractive taste modalities in humans. T1Rs are candidate mammalian taste receptors that combine to assemble two heteromeric G-protein-coupled receptor complexes: T1R1+3, an umami sensor, and T1R2+3, a sweet receptor. We now report the behavioral and physiological characterization of T1R1, T1R2, and T1R3 knockout mice. We demonstrate that sweet and umami taste are strictly dependent on T1R-receptors, and show that selective… CONTINUE READING
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