The Receptors for Mammalian Sweet and Umami Taste

@article{Zhao2003TheRF,
  title={The Receptors for Mammalian Sweet and Umami Taste},
  author={G. Zhao and Y. Zhang and M. Hoon and J. Chandrashekar and I. Erlenbach and N. Ryba and C. Zuker},
  journal={Cell},
  year={2003},
  volume={115},
  pages={255-266}
}
Sweet and umami (the taste of monosodium glutamate) are the main attractive taste modalities in humans. T1Rs are candidate mammalian taste receptors that combine to assemble two heteromeric G-protein-coupled receptor complexes: T1R1+3, an umami sensor, and T1R2+3, a sweet receptor. We now report the behavioral and physiological characterization of T1R1, T1R2, and T1R3 knockout mice. We demonstrate that sweet and umami taste are strictly dependent on T1R-receptors, and show that selective… Expand
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References

SHOWING 1-10 OF 57 REFERENCES
Detection of Sweet and Umami Taste in the Absence of Taste Receptor T1r3
  • 502
  • Highly Influential
A family of candidate taste receptors in human and mouse
  • 596
  • PDF
Coding of Sweet, Bitter, and Umami Tastes Different Receptor Cells Sharing Similar Signaling Pathways
  • 1,029
  • PDF
T2Rs Function as Bitter Taste Receptors
  • 1,142
  • PDF
Human receptors for sweet and umami taste
  • 1,068
  • PDF
Mammalian Sweet Taste Receptors
  • 926
  • PDF
A Plethora of Taste Receptors
  • 32
An amino-acid taste receptor
  • 1,162
  • PDF
The Taste of Monosodium Glutamate: Membrane Receptors in Taste Buds
  • 258
  • PDF
...
1
2
3
4
5
...