The Receptors for Mammalian Sweet and Umami Taste

@article{Zhao2003TheRF,
  title={The Receptors for Mammalian Sweet and Umami Taste},
  author={Grace Q. Zhao and Yifeng Zhang and Mark A. Hoon and Jayaram Chandrashekar and Isolde Erlenbach and Nicholas J. P. Ryba and Charles S. Zuker},
  journal={Cell},
  year={2003},
  volume={115},
  pages={255-266}
}
Sweet and umami (the taste of monosodium glutamate) are the main attractive taste modalities in humans. T1Rs are candidate mammalian taste receptors that combine to assemble two heteromeric G-protein-coupled receptor complexes: T1R1+3, an umami sensor, and T1R2+3, a sweet receptor. We now report the behavioral and physiological characterization of T1R1, T1R2, and T1R3 knockout mice. We demonstrate that sweet and umami taste are strictly dependent on T1R-receptors, and show that selective… 

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