The Receptor for the Cytotoxic Ligand TRAIL

@inproceedings{Pan1997TheRF,
  title={The Receptor for the Cytotoxic Ligand TRAIL},
  author={Guohua Pan and Karen O'rourke and Arul M. Chinnaiyan and Reiner L. Gentz and Reinhard Ebner and Jian Ni and Vishva M. Dixit},
  booktitle={Science},
  year={1997}
}
TRAIL (also known as Apo-2L) is a member of the tumor necrosis factor (TNF) ligand family that rapidly induces apoptosis in a variety of transformed cell lines. The human receptor for TRAIL was found to be an undescribed member of the TNF-receptor family (designated death receptor-4, DR4) that contains a cytoplasmic “death domain” capable of engaging the cell suicide apparatus but not the nuclear factor kappa B pathway in the system studied. Unlike Fas, TNFR-1, and DR3, DR4 could not use FADD… 
Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors.
TLDR
A cell surface mechanism exists for the regulation of cellular responsiveness to pro-apoptotic stimuli in tumor cells.
TRAIL receptor-2 signals apoptosis through FADD and caspase-8
TLDR
Investigation of the intracellular signalling pathways responsible for TRAIL-receptor-induced apoptosis has produced controversial results, and genetic evidence indicates the C gene is responsible for apoptosis.
Biochemical analysis of the native TRAIL death-inducing signaling complex.
TLDR
Interestingly, treatment of TRAil-resistant tumor cells with conventional chemotherapeutic drugs or with proteasome inhibitors renders these cells sensitive for TRAIL-induced apoptosis, according to the methodology of the biochemical analysis of the TRAIL DISC.
TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling
TLDR
E ectopic expression of TRUNDD attenuated TRAIL‐induced apoptosis in mammalian cells and was detected in multiple human tissues, indicating an inhibitory role.
Transcriptional regulation of the TRAIL-R3 gene.
TLDR
Cl cloning and analysis of the TRAIL-R3 promoter will help to identify the cellular factors that regulate its transcriptional expression and outline directions for future research.
TNF-related apoptosis-inducing ligand: signalling of a 'smart' molecule.
TLDR
The potential use of TRAIL as anticancer treatment alone or in combination therapy as well as the use of drugs which signal via TRAIL and its receptors will be analyzed.
Onto better TRAILs for cancer treatment
TLDR
This review summarizes these second-generation novel formulations of TRAIL and other TRAIL-R agonists, which exhibit enhanced cytotoxic capacity toward cancer cells, thereby providing the potential of being more effective when applied clinically than first-generation TRAil- R agonists.
TNF-related apoptosis inducing ligand (TRAIL) and its receptors in tumor surveillance and cancer therapy
TLDR
This review discusses the molecular basis of the cooperation of TRAIL and chemotherapeutic drugs, and debates controversial data in the literature concerning the cytotoxicity of different TRAIL derivatives on primary human cells.
Therapeutic applications of TRAIL receptor agonists in cancer and beyond.
TLDR
The biochemical pathways used by TRAIL to induce different cell death programs are described and some of these conditions where modulation of the TRAIL/TRAIL receptor system may be targeted in the future are highlighted.
An antagonist decoy receptor and a death domain-containing receptor for TRAIL.
TLDR
Ectopic expression of TRID protected mammalian cells from TRAIL-induced apoptosis, which is consistent with a protective role.
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